Mehmed Safayhi served as director of the Süleymaniye Manuscript Library from 1937 until November 30, 1970, and was appointed as a classification clerk in 1940. According to a document sent by the Ministry of National Education on June 23, 1961, at the request of Süleymaniye Library Director Halit Dener, Mehmed Safayhi completed his higher education by obtaining a madrasa certificate from teacher Gürdolusu Emin Efendi on 8 Cemaziyelevvel 1332 (April 4, 1914). He retired on November 30, 1970, due to age.
Mehmed Safayhi, who passed away on October 7, 1977, is buried in the Beşiktaş Yahya Efendi Dergâhı Haziresi, next to Abdülhay Öztoprak, the last sheikh of the dergâh and also his father-in-law.